Chimeric Antigen Receptor T Cell Therapies For Multiple Myeloma

Despite promising objective response rates most patients relapse and low levels of bcma on a subset of tumor cells has been suggested as a probable escape mechanism.

Chimeric antigen receptor t cell therapies for multiple myeloma.

5 6 18 20 cars are. B cell maturation antigen bcma is a validated target for chimeric antigen receptor car t cell therapy in multiple myeloma mm. Multiple myeloma mm is a nearly always incurable malignancy of plasma cells so new approaches to treatment are needed. Chimeric antigen receptor t cell therapy for multiple myeloma.

5 6 18 t cells expressing a car can specifically recognize a targeted antigen which is an advantage of car t cells over nonspecific cellular therapies such as allogeneic hematopoietic stem cell transplantation. Dimopoulos 8 paulo lucio 9 joan bladé 10 michel delforge 11 roman. Chimeric antigen receptors cars are fusion. Disease settings where clinical evaluation of car t cell therapy has been reported advanced relapse refractory disease.

Cars are artificial fusion proteins that incorporate an antigen recognition domain and t cell signaling domains. T cell therapies are a promising approach for treating mm with a mechanism of action different than those of standard mm treatments. There is an unmet need to develop novel therapies for refractory relapsed mm. We conducted the first in humans clinical trial of chimeric antigen receptor car t cells targeting bcma.

Potential and currently studied settings for the use of car chimeric antigen receptor t cell therapy in the management of multiple myeloma through the natural history of the disease. B cell maturation antigen bcma is expressed in most cases of mm. Therapies with novel mechanisms of action are needed for multiple myeloma mm. T cells expressing the car used in this work.

In this phase 1 study involving patients with relapsed or refractory multiple myeloma we administered bb2121 as a single infusion at doses of 50 10 6 150 10 6 450 10 6 or 800 10. Preclinical studies suggest that bb2121 a chimeric antigen receptor car t cell therapy that targets b cell maturation antigen bcma has potential for the treatment of multiple myeloma.